Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528904..3529522 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QN220_RS17020 Protein ID WP_001291435.1
Coordinates 3529304..3529522 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag QN220_RS17015 Protein ID WP_200931917.1
Coordinates 3528904..3529278 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS17005 (3523993) 3523993..3525186 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN220_RS17010 (3525209) 3525209..3528358 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QN220_RS17015 (3528904) 3528904..3529278 + 375 WP_200931917.1 Hha toxicity modulator TomB Antitoxin
QN220_RS17020 (3529304) 3529304..3529522 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QN220_RS17025 (3529694) 3529694..3530245 + 552 WP_153443482.1 maltose O-acetyltransferase -
QN220_RS17030 (3530361) 3530361..3530831 + 471 WP_000136192.1 YlaC family protein -
QN220_RS17035 (3530995) 3530995..3532545 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QN220_RS17040 (3532587) 3532587..3532940 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QN220_RS17050 (3533319) 3533319..3533630 + 312 WP_000409911.1 MGMT family protein -
QN220_RS17055 (3533661) 3533661..3534233 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282861 WP_001291435.1 NZ_CP126343:3529304-3529522 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.42 Da        Isoelectric Point: 4.9284

>AT282861 WP_200931917.1 NZ_CP126343:3528904-3529278 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDRQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References