Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2355329..2356917 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag QN220_RS11385 Protein ID WP_001125439.1
Coordinates 2355595..2356917 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QN220_RS11380 Protein ID WP_284562228.1
Coordinates 2355329..2355595 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS11370 (2350507) 2350507..2351475 + 969 WP_031942297.1 IS5-like element IS903B family transposase -
QN220_RS11375 (2351534) 2351534..2355106 + 3573 Protein_2225 ECSE_1600 family autotransporter -
QN220_RS11380 (2355329) 2355329..2355595 + 267 WP_284562228.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QN220_RS11385 (2355595) 2355595..2356917 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QN220_RS11390 (2357229) 2357229..2357437 + 209 Protein_2228 AraC family transcriptional regulator -
QN220_RS11395 (2357692) 2357692..2358918 + 1227 Protein_2229 fimbria/pilus outer membrane usher protein -
QN220_RS11400 (2358932) 2358932..2359462 + 531 WP_000876770.1 fimbrial protein -
QN220_RS11405 (2359475) 2359475..2359978 + 504 WP_001556576.1 fimbrial protein -
QN220_RS11410 (2360038) 2360038..2360952 + 915 WP_000520659.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2349150..2368139 18989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T282858 WP_001125439.1 NZ_CP126343:2355595-2356917 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10017.32 Da        Isoelectric Point: 4.6280

>AT282858 WP_284562228.1 NZ_CP126343:2355329-2355595 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAENASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References