Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875615..876269 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QN220_RS04300 Protein ID WP_000244777.1
Coordinates 875862..876269 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QN220_RS04295 Protein ID WP_000354046.1
Coordinates 875615..875881 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS04275 (871584) 871584..873017 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
QN220_RS04280 (873062) 873062..873373 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
QN220_RS04285 (873537) 873537..874196 + 660 WP_000250274.1 hemolysin III family protein -
QN220_RS04290 (874392) 874392..875372 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
QN220_RS04295 (875615) 875615..875881 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QN220_RS04300 (875862) 875862..876269 + 408 WP_000244777.1 protein YgfX Toxin
QN220_RS04305 (876309) 876309..876830 - 522 WP_001055874.1 flavodoxin FldB -
QN220_RS04310 (876942) 876942..877838 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QN220_RS04315 (877863) 877863..878573 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QN220_RS04320 (878579) 878579..880312 + 1734 WP_284562167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T282850 WP_000244777.1 NZ_CP126343:875862-876269 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT282850 WP_000354046.1 NZ_CP126343:875615-875881 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References