Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4593380..4594519 Replicon chromosome
Accession NZ_CP126342
Organism Pseudomonas otitidis strain TL17

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QN096_RS21145 Protein ID WP_044405542.1
Coordinates 4593380..4594129 (-) Length 250 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1E4WFB3
Locus tag QN096_RS21150 Protein ID WP_044405544.1
Coordinates 4594148..4594519 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN096_RS21135 (QN096_21135) 4591051..4592412 - 1362 WP_174244768.1 DNA recombination protein RmuC -
QN096_RS21140 (QN096_21140) 4592579..4592992 - 414 WP_107330690.1 SEL1-like repeat protein -
QN096_RS21145 (QN096_21145) 4593380..4594129 - 750 WP_044405542.1 RES family NAD+ phosphorylase Toxin
QN096_RS21150 (QN096_21150) 4594148..4594519 - 372 WP_044405544.1 XRE family transcriptional regulator Antitoxin
QN096_RS21155 (QN096_21155) 4594652..4595134 + 483 WP_160482897.1 GreA/GreB family elongation factor -
QN096_RS21160 (QN096_21160) 4595171..4595566 + 396 WP_279811418.1 hypothetical protein -
QN096_RS21165 (QN096_21165) 4595770..4595943 + 174 WP_167368480.1 hypothetical protein -
QN096_RS21170 (QN096_21170) 4595971..4596396 - 426 WP_284547012.1 S24 family peptidase -
QN096_RS21175 (QN096_21175) 4596506..4598110 - 1605 WP_284547013.1 M28 family metallopeptidase -
QN096_RS21180 (QN096_21180) 4598386..4599051 - 666 WP_044405551.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(58-205)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 250 a.a.        Molecular weight: 28131.02 Da        Isoelectric Point: 6.9626

>T282846 WP_044405542.1 NZ_CP126342:c4594129-4593380 [Pseudomonas otitidis]
MDIWSACDGERHIAPLRGRVVRLVESQEQVATLQLVDNLAEQALLEELIETSKPPLPRSAEPLHYLLKTPFRYPPLRWGS
RFGTVHEPSLFYAAARLETAMAEGAFYRFVLWSGMATPPPSGRILSEHASFEARFQVERGVSLQNPPFDAYPALLDRRDY
RATQALGAAMRAAGVEAFEYRSARCPQQGLNIALFTPDAFTERRPRNLTPWFCETTADYVAYKHAQAPDQPRLFRREAFL
VDGVIPQPA

Download         Length: 750 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13690.98 Da        Isoelectric Point: 10.6556

>AT282846 WP_044405544.1 NZ_CP126342:c4594519-4594148 [Pseudomonas otitidis]
MSALTRPHLDPDAVLAKALLNTREQLGLTRQQLADIVGVHRTVVTRWADAGSIRPQSKTGELALLVIRIYRALFALFGGN
LEDMRHFLRTENRHLGGVPLELMGQVQGLVRVVEYLDAIRGKV

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4WFB3

References