Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4952203..4952819 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QN095_RS23510 Protein ID WP_080292722.1
Coordinates 4952203..4952574 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QN095_RS23515 Protein ID WP_046889539.1
Coordinates 4952577..4952819 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS23495 (QN095_23495) 4949703..4950605 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
QN095_RS23500 (QN095_23500) 4950602..4951237 + 636 WP_013099357.1 formate dehydrogenase cytochrome b556 subunit -
QN095_RS23505 (QN095_23505) 4951234..4952163 + 930 WP_029882351.1 formate dehydrogenase accessory protein FdhE -
QN095_RS23510 (QN095_23510) 4952203..4952574 - 372 WP_080292722.1 type II toxin-antitoxin system VapC family toxin Toxin
QN095_RS23515 (QN095_23515) 4952577..4952819 - 243 WP_046889539.1 ribbon-helix-helix domain-containing protein Antitoxin
QN095_RS23520 (QN095_23520) 4953019..4953936 + 918 WP_161670269.1 alpha/beta hydrolase -
QN095_RS23525 (QN095_23525) 4953949..4954890 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
QN095_RS23530 (QN095_23530) 4954935..4955372 - 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
QN095_RS23535 (QN095_23535) 4955369..4956250 - 882 WP_013099364.1 virulence factor BrkB family protein -
QN095_RS23540 (QN095_23540) 4956244..4956843 - 600 WP_013099365.1 glucose-1-phosphatase -
QN095_RS23545 (QN095_23545) 4956963..4957763 - 801 WP_020686879.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13657.75 Da        Isoelectric Point: 6.6407

>T282843 WP_080292722.1 NZ_CP126341:c4952574-4952203 [Enterobacter cloacae]
MNNMAVFDTNILIDLFNNRVEAADAIDHAASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFSGIDEVVTPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9413.69 Da        Isoelectric Point: 4.3224

>AT282843 WP_046889539.1 NZ_CP126341:c4952819-4952577 [Enterobacter cloacae]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRDALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References