Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4195167..4195948 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QN095_RS19885 Protein ID WP_284557617.1
Coordinates 4195167..4195658 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A5E1AUV7
Locus tag QN095_RS19890 Protein ID WP_029882966.1
Coordinates 4195655..4195948 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS19865 (QN095_19865) 4190907..4191599 + 693 WP_013098687.1 response regulator -
QN095_RS19870 (QN095_19870) 4191698..4193833 - 2136 WP_161670618.1 ornithine decarboxylase -
QN095_RS19875 (QN095_19875) 4194016..4194729 + 714 WP_013098689.1 DUF554 domain-containing protein -
QN095_RS19885 (QN095_19885) 4195167..4195658 - 492 WP_284557617.1 GNAT family N-acetyltransferase Toxin
QN095_RS19890 (QN095_19890) 4195655..4195948 - 294 WP_029882966.1 DUF1778 domain-containing protein Antitoxin
QN095_RS19895 (QN095_19895) 4196197..4197984 - 1788 WP_038983508.1 hybrid sensor histidine kinase/response regulator -
QN095_RS19900 (QN095_19900) 4197981..4198613 - 633 WP_013098693.1 response regulator transcription factor -
QN095_RS19905 (QN095_19905) 4198789..4199103 + 315 WP_013098694.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17629.53 Da        Isoelectric Point: 7.2653

>T282842 WP_284557617.1 NZ_CP126341:c4195658-4195167 [Enterobacter cloacae]
MISAPEPLHAGHIITPFCCGVDSMDNWLKQRAMKNQVSGASRTFVCCGNDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLM
ASI

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11003.66 Da        Isoelectric Point: 9.9156

>AT282842 WP_029882966.1 NZ_CP126341:c4195948-4195655 [Enterobacter cloacae]
MPAANTMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
ATLRKTMQTPAPWEREK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AUV7

References