Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3385076..3386859 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QN095_RS16005 Protein ID WP_095908042.1
Coordinates 3385076..3386425 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QN095_RS16010 Protein ID WP_029883072.1
Coordinates 3386422..3386859 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS15975 (QN095_15975) 3380231..3381028 - 798 WP_095452803.1 helix-turn-helix transcriptional regulator -
QN095_RS15980 (QN095_15980) 3381088..3381804 + 717 WP_094916089.1 type 1 glutamine amidotransferase -
QN095_RS15985 (QN095_15985) 3381996..3382394 + 399 WP_023619766.1 CidA/LrgA family protein -
QN095_RS15990 (QN095_15990) 3382391..3383086 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
QN095_RS15995 (QN095_15995) 3383216..3384100 + 885 WP_108452890.1 cytidine deaminase -
QN095_RS16000 (QN095_16000) 3384228..3384941 + 714 WP_023619764.1 outer membrane permeability protein SanA -
QN095_RS16005 (QN095_16005) 3385076..3386425 + 1350 WP_095908042.1 HipA domain-containing protein Toxin
QN095_RS16010 (QN095_16010) 3386422..3386859 + 438 WP_029883072.1 helix-turn-helix transcriptional regulator Antitoxin
QN095_RS16015 (QN095_16015) 3386911..3387921 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
QN095_RS16020 (QN095_16020) 3387937..3389457 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
QN095_RS16025 (QN095_16025) 3389538..3390536 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
QN095_RS16030 (QN095_16030) 3390832..3391854 - 1023 WP_020690130.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-403)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51227.82 Da        Isoelectric Point: 4.5722

>T282840 WP_095908042.1 NZ_CP126341:3385076-3386425 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVSDVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDSIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIMRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPIYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT282840 WP_029883072.1 NZ_CP126341:3386422-3386859 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References