Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1252411..1253031 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag QN095_RS05895 Protein ID WP_013095889.1
Coordinates 1252411..1252629 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag QN095_RS05900 Protein ID WP_008499288.1
Coordinates 1252657..1253031 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS05865 (QN095_05865) 1248423..1248683 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
QN095_RS05870 (QN095_05870) 1248686..1248826 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QN095_RS05875 (QN095_05875) 1248823..1249533 - 711 WP_023620096.1 GNAT family protein -
QN095_RS05880 (QN095_05880) 1249635..1251095 + 1461 WP_150057013.1 PLP-dependent aminotransferase family protein -
QN095_RS05885 (QN095_05885) 1251067..1251534 - 468 WP_013095887.1 YlaC family protein -
QN095_RS05890 (QN095_05890) 1251650..1252201 - 552 WP_013095888.1 maltose O-acetyltransferase -
QN095_RS05895 (QN095_05895) 1252411..1252629 - 219 WP_013095889.1 HHA domain-containing protein Toxin
QN095_RS05900 (QN095_05900) 1252657..1253031 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
QN095_RS05905 (QN095_05905) 1253544..1256690 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
QN095_RS05910 (QN095_05910) 1256713..1257906 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T282835 WP_013095889.1 NZ_CP126341:c1252629-1252411 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT282835 WP_008499288.1 NZ_CP126341:c1253031-1252657 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References