Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 712545..713339 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag QN095_RS03390 Protein ID WP_038418617.1
Coordinates 712545..713066 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A5E1AP76
Locus tag QN095_RS03395 Protein ID WP_013095428.1
Coordinates 713070..713339 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS03365 (QN095_03365) 707872..708033 + 162 WP_020687816.1 DUF1127 domain-containing protein -
QN095_RS03370 (QN095_03370) 708120..709508 - 1389 WP_047023206.1 PLP-dependent aminotransferase family protein -
QN095_RS03375 (QN095_03375) 709611..710090 + 480 WP_013095424.1 carboxymuconolactone decarboxylase family protein -
QN095_RS03380 (QN095_03380) 710077..710979 - 903 WP_094085398.1 LysR family transcriptional regulator -
QN095_RS03385 (QN095_03385) 711080..712495 + 1416 WP_161670545.1 aldehyde dehydrogenase family protein -
QN095_RS03390 (QN095_03390) 712545..713066 - 522 WP_038418617.1 GNAT family N-acetyltransferase Toxin
QN095_RS03395 (QN095_03395) 713070..713339 - 270 WP_013095428.1 DUF1778 domain-containing protein Antitoxin
QN095_RS03400 (QN095_03400) 713554..713877 + 324 WP_284557736.1 antibiotic biosynthesis monooxygenase -
QN095_RS03405 (QN095_03405) 713870..714268 + 399 WP_029882197.1 hypothetical protein -
QN095_RS03410 (QN095_03410) 714240..714935 + 696 WP_038418621.1 winged helix-turn-helix domain-containing protein -
QN095_RS03415 (QN095_03415) 715054..716200 + 1147 Protein_664 IS481 family transposase -
QN095_RS03420 (QN095_03420) 716423..716893 + 471 WP_013095432.1 MarR family transcriptional regulator -
QN095_RS03425 (QN095_03425) 716890..717957 + 1068 WP_114519182.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-157)

Antitoxin

Vibrio phage ICP1, Orf50

(3-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19352.30 Da        Isoelectric Point: 9.4920

>T282834 WP_038418617.1 NZ_CP126341:c713066-712545 [Enterobacter cloacae]
VNNMKIGIFSDDVEYDLSHFDCGEESLNTFLTAHLKRQHRGKFLRGYVLVASGEKPRVLGYYTLSGSCFEKAYLPSKTQQ
KRVPYKNVPSVTLGRLAIDKRFQGQGLGELLVTHALKTVYLASFAVGIHGIFVEALNGSAKNFYLKLGFIALQAENENTL
FLPTKTIERLFAD

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.54 Da        Isoelectric Point: 5.8652

>AT282834 WP_013095428.1 NZ_CP126341:c713339-713070 [Enterobacter cloacae]
MSALKKQRIDLRLTEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIEQHRRLILNEASWNQVMDAISNPPTPNERLKR
AARRLQDLE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AP76

References