Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 633627..634143 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name relE Uniprot ID A0A5E1ALA9
Locus tag QN095_RS03050 Protein ID WP_038985641.1
Coordinates 633859..634143 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag QN095_RS03045 Protein ID WP_008501400.1
Coordinates 633627..633869 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS03030 (QN095_03030) 629616..630356 + 741 WP_094085364.1 KDGP aldolase family protein -
QN095_RS03035 (QN095_03035) 630480..631619 + 1140 WP_095453858.1 lactonase family protein -
QN095_RS03040 (QN095_03040) 631639..633549 + 1911 WP_161670021.1 PRD domain-containing protein -
QN095_RS03045 (QN095_03045) 633627..633869 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QN095_RS03050 (QN095_03050) 633859..634143 + 285 WP_038985641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN095_RS03055 (QN095_03055) 634147..634611 - 465 WP_161670019.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QN095_RS03060 (QN095_03060) 634734..636872 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
QN095_RS03065 (QN095_03065) 637246..638889 - 1644 WP_161670018.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11014.93 Da        Isoelectric Point: 10.4610

>T282833 WP_038985641.1 NZ_CP126341:633859-634143 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT282833 WP_008501400.1 NZ_CP126341:633627-633869 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1ALA9

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References