Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 181762..182366 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QN095_RS00875 Protein ID WP_161670311.1
Coordinates 181762..181947 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E1AFC9
Locus tag QN095_RS00880 Protein ID WP_023621194.1
Coordinates 181962..182366 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS00860 (QN095_00860) 178193..179731 + 1539 WP_020686520.1 aldehyde dehydrogenase family protein -
QN095_RS00865 (QN095_00865) 179728..180693 - 966 WP_061771396.1 LysR family transcriptional regulator -
QN095_RS00870 (QN095_00870) 180811..181551 + 741 WP_013094942.1 MipA/OmpV family protein -
QN095_RS00875 (QN095_00875) 181762..181947 + 186 WP_161670311.1 type II toxin-antitoxin system HicA family toxin Toxin
QN095_RS00880 (QN095_00880) 181962..182366 + 405 WP_023621194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QN095_RS00885 (QN095_00885) 182420..184375 - 1956 WP_161670310.1 glycoside hydrolase family 127 protein -
QN095_RS00890 (QN095_00890) 184386..185786 - 1401 WP_161670309.1 MFS transporter -
QN095_RS00895 (QN095_00895) 186011..186829 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6901.16 Da        Isoelectric Point: 11.7891

>T282831 WP_161670311.1 NZ_CP126341:181762-181947 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKVSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14888.72 Da        Isoelectric Point: 4.3036

>AT282831 WP_023621194.1 NZ_CP126341:181962-182366 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFC9

References