Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 59612..60274 Replicon chromosome
Accession NZ_CP126341
Organism Enterobacter cloacae strain TL15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QN095_RS00295 Protein ID WP_020686448.1
Coordinates 59876..60274 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5E1AFU3
Locus tag QN095_RS00290 Protein ID WP_020686447.1
Coordinates 59612..59872 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN095_RS00275 (QN095_00275) 57038..58159 - 1122 WP_097535494.1 efflux RND transporter periplasmic adaptor subunit -
QN095_RS00280 (QN095_00280) 58308..58877 - 570 WP_013094828.1 TetR/AcrR family transcriptional regulator -
QN095_RS00285 (QN095_00285) 59065..59484 + 420 WP_048972221.1 GNAT family N-acetyltransferase -
QN095_RS00290 (QN095_00290) 59612..59872 + 261 WP_020686447.1 virulence protein Antitoxin
QN095_RS00295 (QN095_00295) 59876..60274 + 399 WP_020686448.1 type II toxin-antitoxin system VapC family toxin Toxin
QN095_RS00300 (QN095_00300) 60415..61215 + 801 WP_062856168.1 lipoprotein NlpA -
QN095_RS00305 (QN095_00305) 61228..61908 - 681 WP_058682901.1 EAL domain-containing protein -
QN095_RS00310 (QN095_00310) 61978..62589 - 612 WP_013094832.1 LuxR C-terminal-related transcriptional regulator -
QN095_RS00315 (QN095_00315) 63037..63702 + 666 WP_020686451.1 LuxR C-terminal-related transcriptional regulator -
QN095_RS00320 (QN095_00320) 63744..64808 - 1065 WP_013094835.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14855.11 Da        Isoelectric Point: 6.7510

>T282830 WP_020686448.1 NZ_CP126341:59876-60274 [Enterobacter cloacae]
MLHMLDTNIVSHLVRQHPGVIKHYSRTPIEKMCISSVTEAELLYGIAKKQSDRLQKTILEFLKTITICDWDSEAAATYGE
LRAEMEKRGRVMGDLDQLIAAHALSRGTTIVTNDHAFRMVQALAVEDWTTAS

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.66 Da        Isoelectric Point: 10.0393

>AT282830 WP_020686447.1 NZ_CP126341:59612-59872 [Enterobacter cloacae]
MKRTAKLFKKGRRQAVMLPADFMFDTESVYIRRDEEGNVILTARSEKERHRDNFLRLLKQTDVPDSFLSKEERNQSYTTR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFU3

References