Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4031568..4033139 Replicon chromosome
Accession NZ_CP126338
Organism Proteus mirabilis strain W2

Toxin (Protein)


Gene name hipA Uniprot ID B4F0T8
Locus tag QN093_RS18625 Protein ID WP_012368637.1
Coordinates 4031568..4032881 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag QN093_RS18630 Protein ID WP_004249771.1
Coordinates 4032882..4033139 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN093_RS18605 (QN093_18605) 4026737..4027540 + 804 WP_004249775.1 energy transducer TonB -
QN093_RS18610 (QN093_18610) 4027594..4029555 - 1962 WP_036971861.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
QN093_RS18615 (QN093_18615) 4029587..4030516 - 930 WP_004246518.1 metallophosphoesterase -
QN093_RS18620 (QN093_18620) 4030701..4031165 - 465 WP_049256373.1 DUF1097 domain-containing protein -
QN093_RS18625 (QN093_18625) 4031568..4032881 - 1314 WP_012368637.1 type II toxin-antitoxin system HipA family toxin Toxin
QN093_RS18630 (QN093_18630) 4032882..4033139 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
QN093_RS18635 (QN093_18635) 4033288..4034652 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
QN093_RS18640 (QN093_18640) 4034790..4036430 - 1641 WP_004246512.1 membrane protein insertase YidC -
QN093_RS18645 (QN093_18645) 4036433..4036693 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
QN093_RS18650 (QN093_18650) 4036657..4037016 - 360 WP_004246510.1 ribonuclease P protein component -
QN093_RS18655 (QN093_18655) 4037034..4037177 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49670.78 Da        Isoelectric Point: 6.5023

>T282817 WP_012368637.1 NZ_CP126338:c4032881-4031568 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT282817 WP_004249771.1 NZ_CP126338:c4033139-4032882 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4F0T8

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References