Detailed information of TA system TA282816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3331896..3333618
• Replicon: chromosome
• Accession: NZ_CP126338
• Organism: Proteus mirabilis strain W2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0U2S2I2
• Locus tag: QN093_RS15520
• Protein ID: WP_064497040.1
• Coordinates: 3332680..3333618 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: QN093_RS15515
• Protein ID: WP_000095577.1
• Coordinates: 3331896..3332687 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QN093_RS15485 (QN093_15485)	3327569..3327850	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
QN093_RS15490 (QN093_15490)	3327847..3328473	+	627	WP_064497042.1	TraE/TraK family type IV conjugative transfer system protein	-
QN093_RS15495 (QN093_15495)	3328457..3329353	+	897	WP_064497055.1	type-F conjugative transfer system secretin TraK	-
QN093_RS15500 (QN093_15500)	3329356..3330645	+	1290	WP_064497041.1	TraB/VirB10 family protein	-
QN093_RS15505 (QN093_15505)	3330720..3331292	+	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
QN093_RS15510 (QN093_15510)	3331289..3331675	+	387	WP_032469918.1	TraA family conjugative transfer protein	-
QN093_RS15515 (QN093_15515)	3331896..3332687	+	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QN093_RS15520 (QN093_15520)	3332680..3333618	+	939	WP_064497040.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QN093_RS15525 (QN093_15525)	3333750..3334442	+	693	WP_001228924.1	DsbC family protein	-
QN093_RS15530 (QN093_15530)	3334442..3336841	+	2400	WP_064497039.1	type IV secretion system protein TraC	-
QN093_RS15535 (QN093_15535)	3336834..3337181	+	348	WP_064497038.1	hypothetical protein	-
QN093_RS15540 (QN093_15540)	3337165..3337677	+	513	WP_175215521.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / aadA2 / ere(A) / dfrA32 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / floR / aph(6)-Id / aph(3'')-Ib / sul2 / tet(C) / aph(3')-Ia / blaCTX-M-65 / fosA3 / aac(3)-IVa / aph(4)-Ia	-	3198373..3388692	190319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-272)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35542.81 Da
• Isoelectric Point: 4.9912

>T282816 WP_064497040.1 NZ_CP126338:3332680-3333618 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT282816 WP_000095577.1 NZ_CP126338:3331896-3332687 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

Structures

Toxin

• AlphaFold DB: A0A0U2S2I2