Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3794622..3796363 Replicon chromosome
Accession NZ_CP126335
Organism Proteus vulgaris strain TAF3

Toxin (Protein)


Gene name hipA Uniprot ID A0A6G6SN80
Locus tag QN092_RS18065 Protein ID WP_072069184.1
Coordinates 3794622..3795995 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6G6SPC9
Locus tag QN092_RS18070 Protein ID WP_072069029.1
Coordinates 3795992..3796363 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN092_RS18050 (QN092_18050) 3790289..3791257 - 969 WP_206535565.1 ABC transporter permease -
QN092_RS18055 (QN092_18055) 3791257..3792840 - 1584 WP_196554480.1 ABC transporter substrate-binding protein -
QN092_RS18060 (QN092_18060) 3793243..3794232 - 990 WP_072069028.1 glycosyltransferase -
QN092_RS18065 (QN092_18065) 3794622..3795995 + 1374 WP_072069184.1 HipA domain-containing protein Toxin
QN092_RS18070 (QN092_18070) 3795992..3796363 + 372 WP_072069029.1 helix-turn-helix transcriptional regulator Antitoxin
QN092_RS18075 (QN092_18075) 3796491..3796991 - 501 WP_072069030.1 hydrogenase maturation peptidase HycI -
QN092_RS18080 (QN092_18080) 3796988..3797398 - 411 WP_072069031.1 formate hydrogenlyase maturation HycH family protein -
QN092_RS18085 (QN092_18085) 3797391..3798173 - 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
QN092_RS18090 (QN092_18090) 3798170..3798724 - 555 WP_036934329.1 hydrogenase 4 subunit H -
QN092_RS18095 (QN092_18095) 3798736..3800469 - 1734 WP_072069033.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52474.27 Da        Isoelectric Point: 4.7625

>T282809 WP_072069184.1 NZ_CP126335:3794622-3795995 [Proteus vulgaris]
MEKITLQAFIVQEWRDIAIIHFPKHDHALYASKYDITYPITELEYETNYSVDYLYRDDNYAVSINHPVALYFDDNGSPGW
LKFLDDIVPSGASRRYWIQYLDIANLTVEQQNYELLYHGTISPIGNLRVKESLPTPSSLNKALVFTIDDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCSKNEEVWIDTYQDDASNLDKYYLVKFPRGNRSSIDCDILRAEYHFYHELTAMGFN
TISIEGMRLEEGNNYPSLWLPRFDIKIENNEVIRLAMESVYSMLNKAPGTTLYHETAIRELIDKINQSNMVTQFGFQFDT
SDFIIEWVRRDLLNIIFGNSDNHGRNTSFIRYNNAIYLAPIYDFAPMKADPEGIARTTKWNSQNEMGGEYSFINIANSLS
DLIPQEQLLNALKETALQLITLKERLEIRGVPTQILTMPSFGFDFIPNKLERWGLLS

Download         Length: 1374 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14015.37 Da        Isoelectric Point: 10.4324

>AT282809 WP_072069029.1 NZ_CP126335:3795992-3796363 [Proteus vulgaris]
MNNVNHKSPINTIPVRASKKRQSVATVDRKEVINQTMSQLLFEEISQGEALKILRIKVLGLNQERYAKLIHISRKTLSEI
ENDKGNYSADIINKVFKPFGLKIGLIPYSPHVLLSLLKEHINE

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SN80

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SPC9

References