Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3687025..3687602 Replicon chromosome
Accession NZ_CP126335
Organism Proteus vulgaris strain TAF3

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag QN092_RS17525 Protein ID WP_023159957.1
Coordinates 3687270..3687602 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QN092_RS17520 Protein ID WP_096864992.1
Coordinates 3687025..3687270 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN092_RS17495 (QN092_17495) 3682517..3683374 - 858 WP_196725495.1 universal stress protein -
QN092_RS17500 (QN092_17500) 3683377..3684855 - 1479 WP_284551165.1 SulP family inorganic anion transporter -
QN092_RS17505 (QN092_17505) 3685140..3685427 - 288 Protein_3402 ArsC/Spx/MgsR family protein -
QN092_RS17510 (QN092_17510) 3685773..3686000 - 228 WP_096864993.1 plasmid partition protein ParG -
QN092_RS17515 (QN092_17515) 3686109..3686732 - 624 WP_250251027.1 AAA family ATPase -
QN092_RS17520 (QN092_17520) 3687025..3687270 + 246 WP_096864992.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QN092_RS17525 (QN092_17525) 3687270..3687602 + 333 WP_023159957.1 endoribonuclease MazF Toxin
QN092_RS17530 (QN092_17530) 3687633..3688013 + 381 WP_096864991.1 hypothetical protein -
QN092_RS17535 (QN092_17535) 3688100..3688243 - 144 WP_071547955.1 Hok/Gef family protein -
QN092_RS17540 (QN092_17540) 3689030..3689727 + 698 WP_211838731.1 IS1 family transposase -
QN092_RS17545 (QN092_17545) 3689878..3690228 + 351 WP_284551775.1 N-acetyltransferase -
QN092_RS17550 (QN092_17550) 3690363..3692030 - 1668 WP_206086779.1 NAD-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(H) mrkF / mrkD / mrkC / mrkB / mrkA 3564796..3766009 201213
- flank IS/Tn - - 3689030..3689305 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T282807 WP_023159957.1 NZ_CP126335:3687270-3687602 [Proteus vulgaris]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8800.23 Da        Isoelectric Point: 5.0508

>AT282807 WP_096864992.1 NZ_CP126335:3687025-3687270 [Proteus vulgaris]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLENLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P1BQ75

Antitoxin

Source ID Structure

References