Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 2555324..2556063 Replicon chromosome
Accession NZ_CP126335
Organism Proteus vulgaris strain TAF3

Toxin (Protein)


Gene name tacT Uniprot ID A0A6G6SNF5
Locus tag QN092_RS12145 Protein ID WP_072068519.1
Coordinates 2555578..2556063 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A6G6SIM7
Locus tag QN092_RS12140 Protein ID WP_072068518.1
Coordinates 2555324..2555590 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN092_RS12105 (QN092_12105) 2550988..2551470 + 483 WP_006533151.1 flagellar basal body-associated protein FliL -
QN092_RS12110 (QN092_12110) 2551476..2552504 + 1029 WP_072068513.1 flagellar motor switch protein FliM -
QN092_RS12115 (QN092_12115) 2552497..2552907 + 411 WP_006533153.1 flagellar motor switch protein FliN -
QN092_RS12120 (QN092_12120) 2552911..2553357 + 447 WP_072068514.1 flagellar biosynthetic protein FliO -
QN092_RS12125 (QN092_12125) 2553357..2554127 + 771 WP_072068515.1 flagellar type III secretion system pore protein FliP -
QN092_RS12130 (QN092_12130) 2554143..2554412 + 270 WP_072068516.1 flagellar biosynthesis protein FliQ -
QN092_RS12135 (QN092_12135) 2554418..2555200 + 783 WP_072068517.1 flagellar biosynthetic protein FliR -
QN092_RS12140 (QN092_12140) 2555324..2555590 + 267 WP_072068518.1 DUF1778 domain-containing protein Antitoxin
QN092_RS12145 (QN092_12145) 2555578..2556063 + 486 WP_072068519.1 GNAT family N-acetyltransferase Toxin
QN092_RS12150 (QN092_12150) 2556158..2557102 - 945 WP_072068520.1 flagellar hook-associated protein FlgL -
QN092_RS12155 (QN092_12155) 2557134..2558786 - 1653 WP_072068521.1 flagellar hook-associated protein FlgK -
QN092_RS12160 (QN092_12160) 2558904..2559890 - 987 WP_072068522.1 flagellar assembly peptidoglycan hydrolase FlgJ -
QN092_RS12165 (QN092_12165) 2559890..2560996 - 1107 WP_072068523.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-81)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17951.68 Da        Isoelectric Point: 9.9332

>T282806 WP_072068519.1 NZ_CP126335:2555578-2556063 [Proteus vulgaris]
MGKITAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFMVCEKNKKRVVGYYSLATGSVNHTEAISHIRHNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKQFYLHNGFKASSTQENTLFLALK
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10039.56 Da        Isoelectric Point: 4.6437

>AT282806 WP_072068518.1 NZ_CP126335:2555324-2555590 [Proteus vulgaris]
MKADVQLNIRAKGSQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SNF5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SIM7

References