Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1473620..1474265 Replicon chromosome
Accession NZ_CP126335
Organism Proteus vulgaris strain TAF3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QN092_RS06740 Protein ID WP_284551573.1
Coordinates 1474080..1474265 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QN092_RS06735 Protein ID WP_164526096.1
Coordinates 1473620..1474033 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN092_RS06710 (QN092_06710) 1469099..1469680 - 582 WP_072069983.1 hypothetical protein -
QN092_RS06715 (QN092_06715) 1470702..1471928 - 1227 WP_164526095.1 dNTP triphosphohydrolase -
QN092_RS06720 (QN092_06720) 1472160..1472354 - 195 Protein_1289 recombinase -
QN092_RS06725 (QN092_06725) 1472485..1472679 + 195 WP_284551572.1 hypothetical protein -
QN092_RS06730 (QN092_06730) 1472810..1473577 + 768 WP_241254040.1 phage terminase large subunit -
QN092_RS06735 (QN092_06735) 1473620..1474033 - 414 WP_164526096.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QN092_RS06740 (QN092_06740) 1474080..1474265 - 186 WP_284551573.1 type II toxin-antitoxin system HicA family toxin Toxin
QN092_RS06745 (QN092_06745) 1474375..1474536 + 162 WP_164526098.1 hypothetical protein -
QN092_RS06750 (QN092_06750) 1474560..1475864 + 1305 WP_241254041.1 hypothetical protein -
QN092_RS06755 (QN092_06755) 1476072..1476725 - 654 WP_164526099.1 type A chloramphenicol O-acetyltransferase -
QN092_RS06760 (QN092_06760) 1476835..1477065 - 231 WP_284551574.1 DNA polymerase III subunit theta -
QN092_RS06770 (QN092_06770) 1477406..1479142 - 1737 WP_115351009.1 LPS biosynthesis-modulating metalloenzyme YejM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage cat - 1472160..1486561 14401


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7035.28 Da        Isoelectric Point: 10.9659

>T282805 WP_284551573.1 NZ_CP126335:c1474265-1474080 [Proteus vulgaris]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQILKSAKLKN

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15237.99 Da        Isoelectric Point: 4.3830

>AT282805 WP_164526096.1 NZ_CP126335:c1474033-1473620 [Proteus vulgaris]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADAKSAIDAHFELLSEKGLDIPSPKSQQEHLINSTGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References