Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 36215..36741 Replicon plasmid pTHA
Accession NZ_CP126330
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QN090_RS22935 Protein ID WP_000323025.1
Coordinates 36454..36741 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag QN090_RS22930 Protein ID WP_000534857.1
Coordinates 36215..36454 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN090_RS22900 (QN090_22900) 31383..32342 + 960 WP_000208727.1 DUF523 and DUF1722 domain-containing protein -
QN090_RS22905 (QN090_22905) 32488..33576 + 1089 WP_000633445.1 AAA family ATPase -
QN090_RS22910 (QN090_22910) 33639..34343 - 705 WP_001067852.1 IS6-like element IS26 family transposase -
QN090_RS22915 (QN090_22915) 34607..35680 - 1074 WP_000557466.1 hypothetical protein -
QN090_RS22920 (QN090_22920) 35724..35873 - 150 WP_000550473.1 hypothetical protein -
QN090_RS22925 (QN090_22925) 36080..36190 - 111 Protein_40 protein YdfV -
QN090_RS22930 (QN090_22930) 36215..36454 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QN090_RS22935 (QN090_22935) 36454..36741 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QN090_RS22940 (QN090_22940) 37045..37827 - 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
QN090_RS22945 (QN090_22945) 37824..38846 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
QN090_RS22950 (QN090_22950) 38985..39209 + 225 Protein_45 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA12 / aadA2 / aac(3)-IVa / aph(4)-Ia / sul2 / floR / tet(D) - 1..85737 85737
- inside IScluster/Tn - - 33639..38846 5207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T282800 WP_000323025.1 NZ_CP126330:36454-36741 [Citrobacter braakii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT282800 WP_000534857.1 NZ_CP126330:36215-36454 [Citrobacter braakii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References