282796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3572011..3572690 Replicon chromosome
Accession NZ_CP126329
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag QN090_RS17330 Protein ID WP_023564453.1
Coordinates 3572349..3572690 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EWR7
Locus tag QN090_RS17325 Protein ID WP_000070396.1
Coordinates 3572011..3572328 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN090_RS17295 (3567699) 3567699..3568604 - 906 WP_139762569.1 dihydrodipicolinate synthase family protein -
QN090_RS17300 (3568609) 3568609..3569397 - 789 WP_165474297.1 IclR family transcriptional regulator -
QN090_RS17305 (3569597) 3569597..3570577 + 981 WP_000019403.1 IS5-like element IS5 family transposase -
QN090_RS17310 (3570812) 3570812..3571270 + 459 WP_000211838.1 antirestriction protein -
QN090_RS17315 (3571286) 3571286..3571762 + 477 WP_000811693.1 RadC family protein -
QN090_RS17320 (3571771) 3571771..3571992 + 222 WP_000691994.1 DUF987 domain-containing protein -
QN090_RS17325 (3572011) 3572011..3572328 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
QN090_RS17330 (3572349) 3572349..3572690 + 342 WP_023564453.1 type IV toxin-antitoxin system toxin YkfI Toxin
QN090_RS17340 (3573313) 3573313..3573657 - 345 WP_284564636.1 isoprenylcysteine carboxylmethyltransferase family protein -
QN090_RS17345 (3573971) 3573971..3575419 - 1449 WP_137367226.1 EAL domain-containing protein -
QN090_RS17355 (3576369) 3576369..3577088 - 720 WP_094761452.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3569597..3576138 6541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12906.98 Da        Isoelectric Point: 9.6543

>T282796 WP_023564453.1 NZ_CP126329:3572349-3572690 [Citrobacter braakii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11982.62 Da        Isoelectric Point: 7.0270

>AT282796 WP_000070396.1 NZ_CP126329:3572011-3572328 [Citrobacter braakii]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EWR7

References