Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3406243..3406863 Replicon chromosome
Accession NZ_CP126329
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QN090_RS16540 Protein ID WP_002892050.1
Coordinates 3406645..3406863 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag QN090_RS16535 Protein ID WP_003021733.1
Coordinates 3406243..3406617 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN090_RS16525 (3401390) 3401390..3402583 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN090_RS16530 (3402606) 3402606..3405755 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
QN090_RS16535 (3406243) 3406243..3406617 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
QN090_RS16540 (3406645) 3406645..3406863 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QN090_RS16545 (3407044) 3407044..3407595 + 552 WP_016155874.1 maltose O-acetyltransferase -
QN090_RS16550 (3407712) 3407712..3408182 + 471 WP_047416865.1 YlaC family protein -
QN090_RS16555 (3408261) 3408261..3408401 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
QN090_RS16560 (3408403) 3408403..3408663 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
QN090_RS16565 (3408852) 3408852..3410405 + 1554 WP_047416867.1 EAL domain-containing protein -
QN090_RS16570 (3410457) 3410457..3410810 - 354 WP_003831033.1 DUF1428 family protein -
QN090_RS16575 (3410875) 3410875..3411504 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282795 WP_002892050.1 NZ_CP126329:3406645-3406863 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT282795 WP_003021733.1 NZ_CP126329:3406243-3406617 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References