Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2251268..2251904 Replicon chromosome
Accession NZ_CP126329
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag QN090_RS10975 Protein ID WP_049259794.1
Coordinates 2251268..2251456 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QN090_RS10980 Protein ID WP_131382557.1
Coordinates 2251488..2251904 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN090_RS10955 (2248046) 2248046..2248276 - 231 WP_016156585.1 DUF2554 family protein -
QN090_RS10960 (2248466) 2248466..2248591 - 126 WP_003020230.1 DUF2474 domain-containing protein -
QN090_RS10965 (2248591) 2248591..2249601 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
QN090_RS10970 (2249601) 2249601..2251004 - 1404 WP_137367004.1 cytochrome ubiquinol oxidase subunit I -
QN090_RS10975 (2251268) 2251268..2251456 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
QN090_RS10980 (2251488) 2251488..2251904 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QN090_RS10985 (2251997) 2251997..2253406 + 1410 WP_202195551.1 PLP-dependent aminotransferase family protein -
QN090_RS10990 (2253736) 2253736..2254881 + 1146 WP_047417375.1 ABC transporter substrate-binding protein -
QN090_RS10995 (2254898) 2254898..2255914 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
QN090_RS11000 (2255915) 2255915..2256859 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T282790 WP_049259794.1 NZ_CP126329:2251268-2251456 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT282790 WP_131382557.1 NZ_CP126329:2251488-2251904 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References