Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 1660193..1660866 | Replicon | chromosome |
| Accession | NC_018649 | ||
| Organism | Leptospirillum ferriphilum ML-04 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | J9ZDM2 |
| Locus tag | LFML04_RS08505 | Protein ID | WP_014961458.1 |
| Coordinates | 1660444..1660866 (+) | Length | 141 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | J9ZE80 |
| Locus tag | LFML04_RS08500 | Protein ID | WP_014961457.1 |
| Coordinates | 1660193..1660447 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFML04_RS08450 | 1655338..1656087 | + | 750 | WP_014961447.1 | Crp/Fnr family transcriptional regulator | - |
| LFML04_RS13565 | 1656683..1656988 | + | 306 | WP_014961450.1 | hypothetical protein | - |
| LFML04_RS13785 | 1657392..1657838 | + | 447 | WP_161781775.1 | hypothetical protein | - |
| LFML04_RS08475 | 1657885..1658163 | - | 279 | WP_014961453.1 | DUF1778 domain-containing protein | - |
| LFML04_RS08485 | 1658441..1658686 | + | 246 | WP_014961455.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LFML04_RS08490 | 1658670..1659071 | + | 402 | WP_014961456.1 | type II toxin-antitoxin system VapC family toxin | - |
| LFML04_RS08495 | 1659298..1659814 | + | 517 | Protein_1579 | Uma2 family endonuclease | - |
| LFML04_RS08500 | 1660193..1660447 | + | 255 | WP_014961457.1 | plasmid stability protein | Antitoxin |
| LFML04_RS08505 | 1660444..1660866 | + | 423 | WP_014961458.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LFML04_RS08510 | 1660889..1661077 | - | 189 | WP_023525255.1 | XRE family transcriptional regulator | - |
| LFML04_RS13790 | 1661153..1661497 | - | 345 | WP_014961460.1 | hypothetical protein | - |
| LFML04_RS13795 | 1661746..1661940 | + | 195 | WP_050995563.1 | hypothetical protein | - |
| LFML04_RS08520 | 1662434..1663000 | + | 567 | WP_014961464.1 | Uma2 family endonuclease | - |
| LFML04_RS12835 | 1663586..1664350 | - | 765 | WP_014961466.1 | HD-GYP domain-containing protein | - |
| LFML04_RS12840 | 1664964..1665515 | - | 552 | WP_014961469.1 | DUF1640 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1582031..1795193 | 213162 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 15145.33 Da Isoelectric Point: 4.8950
>T28279 WP_014961458.1 NC_018649:1660444-1660866 [Leptospirillum ferriphilum ML-04]
MIVLDTNVVSEAMKPEPQPSVQAWLDRQTAETLYLSSVTIAELLFGIRSLPAGRRRKILDATLEGLLALFGERVLPFDTD
AARHFGELAVTARSAGKGFPTPDDYIAAIAASRGFIVATRDVSSFQAAGLKVINPWEAET
MIVLDTNVVSEAMKPEPQPSVQAWLDRQTAETLYLSSVTIAELLFGIRSLPAGRRRKILDATLEGLLALFGERVLPFDTD
AARHFGELAVTARSAGKGFPTPDDYIAAIAASRGFIVATRDVSSFQAAGLKVINPWEAET
Download Length: 423 bp
>T28279 NC_018649:1660444-1660866 [Leptospirillum ferriphilum ML-04]
ATGATCGTTCTGGATACCAACGTCGTCTCCGAGGCGATGAAGCCGGAGCCGCAACCGTCCGTACAGGCTTGGCTGGACAG
GCAAACAGCGGAAACCCTTTACCTGTCGAGCGTAACCATTGCCGAATTGCTGTTCGGCATCCGTTCTCTGCCAGCAGGGC
GGCGCAGGAAGATCCTGGATGCGACGTTGGAAGGCTTGCTGGCATTGTTCGGAGAGCGCGTCTTGCCATTCGACACAGAC
GCCGCCCGACACTTCGGTGAGCTGGCTGTGACGGCAAGGTCTGCCGGGAAAGGTTTTCCGACACCGGACGACTATATCGC
AGCGATTGCGGCTTCTCGGGGCTTCATTGTCGCCACGCGCGATGTCTCCTCATTCCAGGCAGCAGGCCTGAAAGTCATCA
ATCCCTGGGAGGCGGAAACATAA
ATGATCGTTCTGGATACCAACGTCGTCTCCGAGGCGATGAAGCCGGAGCCGCAACCGTCCGTACAGGCTTGGCTGGACAG
GCAAACAGCGGAAACCCTTTACCTGTCGAGCGTAACCATTGCCGAATTGCTGTTCGGCATCCGTTCTCTGCCAGCAGGGC
GGCGCAGGAAGATCCTGGATGCGACGTTGGAAGGCTTGCTGGCATTGTTCGGAGAGCGCGTCTTGCCATTCGACACAGAC
GCCGCCCGACACTTCGGTGAGCTGGCTGTGACGGCAAGGTCTGCCGGGAAAGGTTTTCCGACACCGGACGACTATATCGC
AGCGATTGCGGCTTCTCGGGGCTTCATTGTCGCCACGCGCGATGTCTCCTCATTCCAGGCAGCAGGCCTGAAAGTCATCA
ATCCCTGGGAGGCGGAAACATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9534.95 Da Isoelectric Point: 6.2327
>AT28279 WP_014961457.1 NC_018649:1660193-1660447 [Leptospirillum ferriphilum ML-04]
MATVTVRNLPDEVHRALRVRASMHGHSTEAEIRSILEATVRPPERLRLGTALTELGRRVGLLEEDFAVFEEVRDKMPAEP
VKFE
MATVTVRNLPDEVHRALRVRASMHGHSTEAEIRSILEATVRPPERLRLGTALTELGRRVGLLEEDFAVFEEVRDKMPAEP
VKFE
Download Length: 255 bp
>AT28279 NC_018649:1660193-1660447 [Leptospirillum ferriphilum ML-04]
ATGGCGACAGTCACCGTTCGAAATCTGCCGGACGAGGTGCACCGTGCTCTTCGGGTGCGAGCGTCGATGCATGGTCACAG
TACCGAGGCGGAAATCCGTTCCATTCTTGAAGCGACTGTCCGGCCACCGGAGCGTCTCCGTTTAGGGACAGCCTTGACGG
AGCTGGGTCGTCGCGTTGGACTTTTGGAGGAGGATTTCGCCGTTTTTGAAGAGGTCCGTGACAAGATGCCGGCTGAGCCC
GTGAAATTTGAATGA
ATGGCGACAGTCACCGTTCGAAATCTGCCGGACGAGGTGCACCGTGCTCTTCGGGTGCGAGCGTCGATGCATGGTCACAG
TACCGAGGCGGAAATCCGTTCCATTCTTGAAGCGACTGTCCGGCCACCGGAGCGTCTCCGTTTAGGGACAGCCTTGACGG
AGCTGGGTCGTCGCGTTGGACTTTTGGAGGAGGATTTCGCCGTTTTTGAAGAGGTCCGTGACAAGATGCCGGCTGAGCCC
GTGAAATTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|