Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872466..873120 Replicon chromosome
Accession NZ_CP126329
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag QN090_RS04380 Protein ID WP_016154348.1
Coordinates 872713..873120 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag QN090_RS04375 Protein ID WP_016154349.1
Coordinates 872466..872732 (+) Length 89 a.a.

Genomic Context


QN090_RS04360QN090_RS04365QN090_RS04375QN090_RS04380QN090_RS04390QN090_RS04395QN090_RS04400QN090_RS04350QN090_RS04355QN090_RS04370QN090_RS04385
Location: 870014..870325 (312 bp)
Type: Others
Protein ID: WP_075847454.1
Location: 870489..871148 (660 bp)
Type: Others
Protein ID: WP_016154351.1
Location: 872466..872732 (267 bp)
Type: Antitoxin
Protein ID: WP_016154349.1
Location: 872713..873120 (408 bp)
Type: Toxin
Protein ID: WP_016154348.1
Location: 873856..874752 (897 bp)
Type: Others
Protein ID: WP_016154346.1
Location: 874776..875489 (714 bp)
Type: Others
Protein ID: WP_075847456.1
Location: 875495..877228 (1734 bp)
Type: Others
Protein ID: WP_049269301.1
Location: 867679..869112 (1434 bp)
Type: Others
Protein ID: WP_075847452.1
Location: 869233..869961 (729 bp)
Type: Others
Protein ID: WP_075847608.1
Location: 871228..872208 (981 bp)
Type: Others
Protein ID: WP_019077629.1
Location: 873221..873742 (522 bp)
Type: Others
Protein ID: WP_016154347.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QN090_RS04350 (867679)867679..869112-1434WP_075847452.16-phospho-beta-glucosidase BglA-
QN090_RS04355 (869233)869233..869961-729WP_075847608.1MurR/RpiR family transcriptional regulator-
QN090_RS04360 (870014)870014..870325+312WP_075847454.1N(4)-acetylcytidine aminohydrolase-
QN090_RS04365 (870489)870489..871148+660WP_016154351.1hemolysin III family protein-
QN090_RS04370 (871228)871228..872208-981WP_019077629.1tRNA-modifying protein YgfZ-
QN090_RS04375 (872466)872466..872732+267WP_016154349.1FAD assembly factor SdhEAntitoxin
QN090_RS04380 (872713)872713..873120+408WP_016154348.1protein YgfXToxin
QN090_RS04385 (873221)873221..873742-522WP_016154347.1flavodoxin FldB-
QN090_RS04390 (873856)873856..874752+897WP_016154346.1site-specific tyrosine recombinase XerD-
QN090_RS04395 (874776)874776..875489+714WP_075847456.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
QN090_RS04400 (875495)875495..877228+1734WP_049269301.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T282789 WP_016154348.1 NZ_CP126329:872713-873120 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT282789 WP_016154349.1 NZ_CP126329:872466-872732 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBR8WN60


Antitoxin

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Source
ID
Structure
AlphaFold DBR8WMJ6

References