Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872466..873120 Replicon chromosome
Accession NZ_CP126329
Organism Citrobacter braakii strain THB2

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag QN090_RS04380 Protein ID WP_016154348.1
Coordinates 872713..873120 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag QN090_RS04375 Protein ID WP_016154349.1
Coordinates 872466..872732 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN090_RS04350 (867679) 867679..869112 - 1434 WP_075847452.1 6-phospho-beta-glucosidase BglA -
QN090_RS04355 (869233) 869233..869961 - 729 WP_075847608.1 MurR/RpiR family transcriptional regulator -
QN090_RS04360 (870014) 870014..870325 + 312 WP_075847454.1 N(4)-acetylcytidine aminohydrolase -
QN090_RS04365 (870489) 870489..871148 + 660 WP_016154351.1 hemolysin III family protein -
QN090_RS04370 (871228) 871228..872208 - 981 WP_019077629.1 tRNA-modifying protein YgfZ -
QN090_RS04375 (872466) 872466..872732 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
QN090_RS04380 (872713) 872713..873120 + 408 WP_016154348.1 protein YgfX Toxin
QN090_RS04385 (873221) 873221..873742 - 522 WP_016154347.1 flavodoxin FldB -
QN090_RS04390 (873856) 873856..874752 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
QN090_RS04395 (874776) 874776..875489 + 714 WP_075847456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QN090_RS04400 (875495) 875495..877228 + 1734 WP_049269301.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T282789 WP_016154348.1 NZ_CP126329:872713-873120 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT282789 WP_016154349.1 NZ_CP126329:872466-872732 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References