Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4299107..4299888 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag QN088_RS20900 Protein ID WP_000625912.1
Coordinates 4299107..4299598 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag QN088_RS20905 Protein ID WP_001110450.1
Coordinates 4299595..4299888 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS20875 (4294247) 4294247..4296685 - 2439 WP_001014138.1 F4 (K88) fimbrial usher FaeD -
QN088_RS20880 (4296695) 4296695..4297234 - 540 WP_284546086.1 fimbrial protein -
QN088_RS20885 (4297269) 4297269..4297559 - 291 WP_000773468.1 PapB/FocB family fimbrial expression transcriptional regulator -
QN088_RS20890 (4298142) 4298142..4298369 + 228 WP_001519955.1 hypothetical protein -
QN088_RS20895 (4298644) 4298644..4298892 - 249 Protein_4084 IS481 family transposase -
QN088_RS20900 (4299107) 4299107..4299598 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
QN088_RS20905 (4299595) 4299595..4299888 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
QN088_RS20910 (4300205) 4300205..4300427 + 223 Protein_4087 hypothetical protein -
QN088_RS20915 (4300692) 4300692..4301567 + 876 WP_000921674.1 AraC family transcriptional regulator -
QN088_RS20920 (4301564) 4301564..4301851 + 288 WP_001541332.1 transcriptional regulator RtsB -
QN088_RS20925 (4301991) 4301991..4302365 + 375 WP_230320449.1 Ig-like domain-containing protein -
QN088_RS20930 (4302660) 4302660..4303565 - 906 WP_284546087.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeH / faeF / faeE / faeD / faeC 4286574..4302365 15791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T282782 WP_000625912.1 NZ_CP126325:c4299598-4299107 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT282782 WP_001110450.1 NZ_CP126325:c4299888-4299595 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References