Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4160469..4160985 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name relE Uniprot ID A0A748AMU5
Locus tag QN088_RS20170 Protein ID WP_023245374.1
Coordinates 4160469..4160753 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QN088_RS20175 Protein ID WP_000212724.1
Coordinates 4160743..4160985 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS20155 (4155585) 4155585..4157237 + 1653 WP_023243275.1 alpha,alpha-phosphotrehalase -
QN088_RS20160 (4157646) 4157646..4159784 + 2139 WP_284546073.1 anaerobic ribonucleoside-triphosphate reductase -
QN088_RS20165 (4160001) 4160001..4160465 + 465 WP_001009176.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QN088_RS20170 (4160469) 4160469..4160753 - 285 WP_023245374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN088_RS20175 (4160743) 4160743..4160985 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QN088_RS20180 (4161063) 4161063..4162976 - 1914 WP_023245375.1 BglG family transcription antiterminator -
QN088_RS20185 (4162993) 4162993..4163733 - 741 WP_000779263.1 KDGP aldolase family protein -
QN088_RS20190 (4163730) 4163730..4164848 - 1119 WP_023245376.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QN088_RS20195 (4164832) 4164832..4165965 - 1134 WP_219557355.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.61 Da        Isoelectric Point: 9.6743

>T282781 WP_023245374.1 NZ_CP126325:c4160753-4160469 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANERL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT282781 WP_000212724.1 NZ_CP126325:c4160985-4160743 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A748AMU5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References