Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4108199..4108749 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag QN088_RS19910 Protein ID WP_001199743.1
Coordinates 4108199..4108507 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag QN088_RS19915 Protein ID WP_000016244.1
Coordinates 4108510..4108749 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS19900 (4103618) 4103618..4107133 - 3516 WP_284546065.1 AAA domain-containing protein -
QN088_RS19905 (4107495) 4107495..4107778 - 284 Protein_3891 Arm DNA-binding domain-containing protein -
QN088_RS19910 (4108199) 4108199..4108507 - 309 WP_001199743.1 CcdB family protein Toxin
QN088_RS19915 (4108510) 4108510..4108749 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QN088_RS19920 (4108862) 4108862..4109110 - 249 WP_000168387.1 ribbon-helix-helix domain-containing protein -
QN088_RS19925 (4109301) 4109301..4109732 - 432 Protein_3895 helix-turn-helix domain-containing protein -
QN088_RS19930 (4110548) 4110548..4112881 - 2334 WP_284546066.1 primase-like DNA-binding domain-containing protein -
QN088_RS19935 (4112896) 4112896..4113216 - 321 WP_284546067.1 DUF5375 domain-containing protein -
QN088_RS19940 (4113213) 4113213..4113440 - 228 WP_023261439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4099246..4121077 21831
- flank IS/Tn - - 4109187..4109687 500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T282780 WP_001199743.1 NZ_CP126325:c4108507-4108199 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T282780 NZ_CP126325:c4108507-4108199 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGATGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT282780 WP_000016244.1 NZ_CP126325:c4108749-4108510 [Salmonella enterica subsp. enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT282780 NZ_CP126325:c4108749-4108510 [Salmonella enterica subsp. enterica]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References