Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4054098..4054674 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag QN088_RS19700 Protein ID WP_001131963.1
Coordinates 4054387..4054674 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag QN088_RS19695 Protein ID WP_000063143.1
Coordinates 4054098..4054400 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS19680 (4050608) 4050608..4052758 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
QN088_RS19685 (4052853) 4052853..4053056 + 204 WP_000460616.1 YbdD/YjiX family protein -
QN088_RS19690 (4053067) 4053067..4054023 + 957 WP_000187838.1 GTPase -
QN088_RS19695 (4054098) 4054098..4054400 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
QN088_RS19700 (4054387) 4054387..4054674 - 288 WP_001131963.1 BrnT family toxin Toxin
QN088_RS19705 (4054943) 4054943..4055857 - 915 WP_000290513.1 restriction endonuclease -
QN088_RS19710 (4056055) 4056055..4059564 + 3510 WP_001043483.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T282779 WP_001131963.1 NZ_CP126325:c4054674-4054387 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT282779 WP_000063143.1 NZ_CP126325:c4054400-4054098 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References