Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3469336..3469956 Replicon chromosome
Accession NZ_CP126325
Organism Salmonella enterica subsp. enterica strain HL21

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QN088_RS16990 Protein ID WP_001280991.1
Coordinates 3469738..3469956 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QN088_RS16985 Protein ID WP_000344807.1
Coordinates 3469336..3469710 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN088_RS16975 (3464475) 3464475..3465668 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN088_RS16980 (3465691) 3465691..3468840 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QN088_RS16985 (3469336) 3469336..3469710 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QN088_RS16990 (3469738) 3469738..3469956 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QN088_RS16995 (3470135) 3470135..3470686 + 552 WP_001278793.1 maltose O-acetyltransferase -
QN088_RS17000 (3470804) 3470804..3471274 + 471 WP_000136183.1 YlaC family protein -
QN088_RS17005 (3471330) 3471330..3471470 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QN088_RS17010 (3471476) 3471476..3471736 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QN088_RS17015 (3471961) 3471961..3473511 + 1551 WP_000213140.1 EAL domain-containing protein -
QN088_RS17025 (3473742) 3473742..3474131 + 390 WP_000961285.1 MGMT family protein -
QN088_RS17030 (3474164) 3474164..3474733 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T282776 WP_001280991.1 NZ_CP126325:3469738-3469956 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT282776 WP_000344807.1 NZ_CP126325:3469336-3469710 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References