Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3987119..3987779 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag QN087_RS19290 Protein ID WP_000244756.1
Coordinates 3987119..3987532 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag QN087_RS19295 Protein ID WP_000351186.1
Coordinates 3987513..3987779 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS19270 (3983060) 3983060..3984793 - 1734 WP_000813390.1 single-stranded-DNA-specific exonuclease RecJ -
QN087_RS19275 (3984799) 3984799..3985512 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QN087_RS19280 (3985536) 3985536..3986432 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
QN087_RS19285 (3986545) 3986545..3987066 + 522 WP_001055885.1 flavodoxin FldB -
QN087_RS19290 (3987119) 3987119..3987532 - 414 WP_000244756.1 protein YgfX Toxin
QN087_RS19295 (3987513) 3987513..3987779 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
QN087_RS19300 (3988029) 3988029..3989009 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
QN087_RS19305 (3989125) 3989125..3989784 - 660 WP_000250289.1 hemolysin III family protein -
QN087_RS19310 (3989948) 3989948..3990259 - 312 WP_001182975.1 N(4)-acetylcytidine aminohydrolase -
QN087_RS19315 (3990417) 3990417..3991850 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T282761 WP_000244756.1 NZ_CP126323:c3987532-3987119 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT282761 WP_000351186.1 NZ_CP126323:c3987779-3987513 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References