282760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3976213..3976856 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag QN087_RS19225 Protein ID WP_000911336.1
Coordinates 3976213..3976611 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5U5RH28
Locus tag QN087_RS19230 Protein ID WP_031606523.1
Coordinates 3976611..3976856 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS19210 (3972890) 3972890..3973471 - 582 WP_001747403.1 fimbrial protein -
QN087_RS19215 (3974190) 3974190..3974822 - 633 WP_000835265.1 YfdX family protein -
QN087_RS19220 (3974869) 3974869..3975405 - 537 WP_001747404.1 STM3031 family outer membrane protein -
QN087_RS19225 (3976213) 3976213..3976611 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
QN087_RS19230 (3976611) 3976611..3976856 - 246 WP_031606523.1 toxin-antitoxin system antitoxin VapB Antitoxin
QN087_RS19235 (3977046) 3977046..3977297 + 252 WP_001576352.1 hypothetical protein -
QN087_RS19240 (3977577) 3977577..3978383 + 807 WP_001574939.1 DUF1460 domain-containing protein -
QN087_RS19250 (3978668) 3978668..3979444 - 777 WP_001747405.1 amidase activator ActS -
QN087_RS19255 (3979709) 3979709..3980254 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
QN087_RS19260 (3980330) 3980330..3981847 - 1518 WP_000003342.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3967768..3978383 10615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T282760 WP_000911336.1 NZ_CP126323:c3976611-3976213 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9088.06 Da        Isoelectric Point: 5.6579

>AT282760 WP_031606523.1 NZ_CP126323:c3976856-3976611 [Salmonella enterica subsp. enterica]
IQKGGSYAHNTFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREG
F

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A5U5RH28

References