Detailed information of TA system TA028276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 251665..252277
• Replicon: chromosome
• Accession: NC_018646
• Organism: Streptococcus agalactiae GD201008-001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: A964_RS01410
• Protein ID: WP_000384860.1
• Coordinates: 251665..252000 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: A964_RS01415
• Protein ID: WP_000259017.1
• Coordinates: 251990..252277 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A964_RS01380	246863..247504	+	642	WP_000591144.1	hypothetical protein	-
A964_RS01390	247804..248679	+	876	WP_000421240.1	hypothetical protein	-
A964_RS01395	248715..249149	+	435	WP_001220479.1	hypothetical protein	-
A964_RS01400	249466..250722	+	1257	WP_000122836.1	plasmid recombination protein	-
A964_RS01405	250890..251360	+	471	WP_000130119.1	hypothetical protein	-
A964_RS01410	251665..252000	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A964_RS01415	251990..252277	-	288	WP_000259017.1	hypothetical protein	Antitoxin
A964_RS01420	252784..253074	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
A964_RS01425	253176..253583	+	408	WP_000749954.1	hypothetical protein	-
A964_RS01430	253583..254143	+	561	WP_001865562.1	hypothetical protein	-
A964_RS01435	254116..254796	+	681	WP_001865565.1	hypothetical protein	-
A964_RS01440	254781..255167	+	387	WP_000259069.1	hypothetical protein	-
A964_RS01445	255201..255482	+	282	WP_000052407.1	hypothetical protein	-
A964_RS01460	256325..257185	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T28276 WP_000384860.1 NC_018646:c252000-251665 [Streptococcus agalactiae GD201008-001]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T28276 NC_018646:c252000-251665 [Streptococcus agalactiae GD201008-001]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT28276 WP_000259017.1 NC_018646:c252277-251990 [Streptococcus agalactiae GD201008-001]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT28276 NC_018646:c252277-251990 [Streptococcus agalactiae GD201008-001]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6