Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 807210..807786 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag QN087_RS03825 Protein ID WP_001131963.1
Coordinates 807210..807497 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag QN087_RS03830 Protein ID WP_000063142.1
Coordinates 807484..807786 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS03805 (802363) 802363..802497 + 135 WP_001055725.1 hypothetical protein -
QN087_RS03810 (802529) 802529..803782 - 1254 WP_001206756.1 N-6 DNA methylase -
QN087_RS03815 (803942) 803942..804361 - 420 WP_001720162.1 restriction endonuclease subunit S -
QN087_RS03820 (804974) 804974..806814 - 1841 Protein_749 3'-5' exonuclease -
QN087_RS03825 (807210) 807210..807497 + 288 WP_001131963.1 BrnT family toxin Toxin
QN087_RS03830 (807484) 807484..807786 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
QN087_RS03835 (807861) 807861..808817 - 957 WP_000187842.1 GTPase -
QN087_RS03840 (808828) 808828..809031 - 204 WP_000460616.1 YbdD/YjiX family protein -
QN087_RS03845 (809126) 809126..811276 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T282751 WP_001131963.1 NZ_CP126323:807210-807497 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT282751 WP_000063142.1 NZ_CP126323:807484-807786 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References