Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 761494..762044 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name ccdB Uniprot ID A0A764IVN5
Locus tag QN087_RS03600 Protein ID WP_001199742.1
Coordinates 761736..762044 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag QN087_RS03595 Protein ID WP_001118105.1
Coordinates 761494..761733 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS03565 (756933) 756933..757964 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
QN087_RS03570 (758181) 758181..758711 + 531 WP_000896758.1 gluconokinase -
QN087_RS03575 (758739) 758739..759758 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
QN087_RS03585 (760515) 760515..761060 + 546 WP_223557450.1 helix-turn-helix domain-containing protein -
QN087_RS03590 (761137) 761137..761385 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
QN087_RS03595 (761494) 761494..761733 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QN087_RS03600 (761736) 761736..762044 + 309 WP_001199742.1 CcdB family protein Toxin
QN087_RS03605 (762450) 762450..762590 + 141 Protein_706 Arm DNA-binding domain-containing protein -
QN087_RS03610 (762622) 762622..763755 - 1134 Protein_707 IS3 family transposase -
QN087_RS03615 (764077) 764077..764607 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
QN087_RS03620 (764729) 764729..765469 + 741 WP_001746655.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 760560..763663 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11826.62 Da        Isoelectric Point: 6.4785

>T282750 WP_001199742.1 NZ_CP126323:761736-762044 [Salmonella enterica subsp. enterica]
MQYMVYHNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT282750 WP_001118105.1 NZ_CP126323:761494-761733 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A764IVN5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References