Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 721329..721845 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name relE Uniprot ID A0A756PF38
Locus tag QN087_RS03400 Protein ID WP_000220583.1
Coordinates 721561..721845 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QN087_RS03395 Protein ID WP_000212724.1
Coordinates 721329..721571 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS03375 (716349) 716349..717482 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
QN087_RS03380 (717466) 717466..718584 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QN087_RS03385 (718581) 718581..719321 + 741 WP_000779259.1 KDGP aldolase family protein -
QN087_RS03390 (719338) 719338..721251 + 1914 WP_001212128.1 BglG family transcription antiterminator -
QN087_RS03395 (721329) 721329..721571 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QN087_RS03400 (721561) 721561..721845 + 285 WP_000220583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN087_RS03405 (721849) 721849..722313 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QN087_RS03410 (722435) 722435..724573 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QN087_RS03415 (724982) 724982..726630 - 1649 Protein_669 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10896.62 Da        Isoelectric Point: 9.6743

>T282749 WP_000220583.1 NZ_CP126323:721561-721845 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDPPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT282749 WP_000212724.1 NZ_CP126323:721329-721571 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A756PF38

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References