Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 614175..614956 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag QN087_RS02825 Protein ID WP_000626100.1
Coordinates 614465..614956 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag QN087_RS02820 Protein ID WP_001110452.1
Coordinates 614175..614468 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS02785 (610230) 610230..611132 + 903 WP_020937303.1 YjiK family protein -
QN087_RS02790 (611422) 611422..611553 - 132 Protein_548 hypothetical protein -
QN087_RS02795 (611665) 611665..611913 - 249 Protein_549 Ig-like domain-containing protein -
QN087_RS02800 (611912) 611912..612220 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
QN087_RS02805 (612213) 612213..612499 - 287 Protein_551 transcriptional regulator RtsB -
QN087_RS02810 (612496) 612496..613371 - 876 WP_000921680.1 AraC family transcriptional regulator -
QN087_RS02815 (613637) 613637..613858 - 222 WP_001576552.1 hypothetical protein -
QN087_RS02820 (614175) 614175..614468 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
QN087_RS02825 (614465) 614465..614956 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
QN087_RS02830 (615204) 615204..615956 - 753 WP_000842432.1 non-specific acid phosphatase -
QN087_RS02835 (616056) 616056..616133 - 78 Protein_557 porin family protein -
QN087_RS02840 (616513) 616513..616587 + 75 Protein_558 helix-turn-helix domain-containing protein -
QN087_RS02850 (616858) 616858..617433 - 576 WP_001188509.1 transcriptional regulator -
QN087_RS02855 (617470) 617470..619173 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
QN087_RS02860 (619149) 619149..619496 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T282748 WP_000626100.1 NZ_CP126323:614465-614956 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT282748 WP_001110452.1 NZ_CP126323:614175-614468 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References