Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1893209..1895028 Replicon chromosome
Accession NZ_CP126169
Organism Rahnella bonaserana strain L46

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QNM34_RS08510 Protein ID WP_284006229.1
Coordinates 1893209..1894558 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QNM34_RS08515 Protein ID WP_217173909.1
Coordinates 1894555..1895028 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM34_RS08485 (QNM34_08485) 1889829..1890041 + 213 WP_284005925.1 hypothetical protein -
QNM34_RS08490 (QNM34_08490) 1890182..1891507 + 1326 WP_284005926.1 heme anaerobic degradation radical SAM methyltransferase ChuW/HutW -
QNM34_RS08495 (QNM34_08495) 1891494..1892000 + 507 WP_284005927.1 heme utilization cystosolic carrier protein HutX -
QNM34_RS08500 (QNM34_08500) 1892003..1892626 + 624 WP_284005928.1 SDR family oxidoreductase -
QNM34_RS08505 (QNM34_08505) 1892794..1893015 + 222 WP_284005929.1 DUF1471 domain-containing protein -
QNM34_RS08510 (QNM34_08510) 1893209..1894558 + 1350 WP_284006229.1 HipA domain-containing protein Toxin
QNM34_RS08515 (QNM34_08515) 1894555..1895028 + 474 WP_217173909.1 helix-turn-helix transcriptional regulator Antitoxin
QNM34_RS08520 (QNM34_08520) 1895081..1895401 - 321 WP_112289135.1 multidrug efflux SMR transporter -
QNM34_RS08525 (QNM34_08525) 1895529..1896995 - 1467 WP_284005930.1 HAMP domain-containing sensor histidine kinase -
QNM34_RS08530 (QNM34_08530) 1896999..1897721 - 723 WP_120162963.1 response regulator transcription factor -
QNM34_RS08535 (QNM34_08535) 1897875..1898501 + 627 WP_113877695.1 cytochrome b/b6 domain-containing protein -
QNM34_RS08540 (QNM34_08540) 1898512..1899315 + 804 WP_284006230.1 molybdopterin-dependent oxidoreductase -
QNM34_RS08545 (QNM34_08545) 1899367..1899663 + 297 WP_284005931.1 pentapeptide MXKDX repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-139)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51124.63 Da        Isoelectric Point: 4.6843

>T282724 WP_284006229.1 NZ_CP126169:1893209-1894558 [Rahnella bonaserana]
MEQLTLQAFLNNEWVDIANITFPDSEQNNYRLTELNYLFDYAIDNLDRDDNRAVSLNHPVALFFDDNGQRGWLKFLDDII
PSGSSRRYWSNYLDLEGLTPDEQNFVLLKHGTLSPVGNLRIKESLPEHNPLAEQLFFTVDDVINRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCNREQQIWIDTYQSDPANRDIPYLVKYPRGARTEVDCNILRAEFHFYHELEAMGFETIPTHNMR
LEEGLSYPSLWLPRFDIAFEEDGVVRRLGMESVNSLLRKAPGVTLYHEETLRTLINQISRSHMVTGQGFSFDIPAFVTEW
VRRDLLNIIFGNSDNHGRNTSFLKDEGSIRLAPIYDFAPMKADPEGIARTTKWKTPLEVGGEYDFPAIAQTLDDLIPAQN
LLRALNETAEQLTGLKDRLAARGIPQQILNMPAISFSFIPEKLRRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17423.13 Da        Isoelectric Point: 11.0971

>AT282724 WP_217173909.1 NZ_CP126169:1894555-1895028 [Rahnella bonaserana]
MKEPLIAADSAKSTIAKIRAKKNAAQRTQSDTAEITNQAERDHAVKTRTRRRVSHLTKPVSANERNEARLQIMRALISGE
ISQGEALKALRINVLGLKQDAFAKLVSVSRKTLSEVENDKGNYTPDIINKLFKPFGLKVGLVPVSQQVLSTLFFNKQ

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References