Detailed information of TA system TA028272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2401540..2402065
• Replicon: chromosome
• Accession: NC_018645
• Organism: Desulfobacula toluolica Tol2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TOL2_RS11020
• Protein ID: WP_041279436.1
• Coordinates: 2401781..2402065 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K0NPI6
• Locus tag: TOL2_RS11015
• Protein ID: WP_014957534.1
• Coordinates: 2401540..2401791 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TOL2_RS10995	2397342..2397533	+	192	WP_014957532.1	hypothetical protein	-
TOL2_RS11000	2397530..2398870	-	1341	WP_014957531.1	group II intron reverse transcriptase/maturase	-
TOL2_RS11005	2399273..2399464	+	192	WP_014957532.1	hypothetical protein	-
TOL2_RS11010	2399461..2400801	-	1341	WP_014957533.1	group II intron reverse transcriptase/maturase	-
TOL2_RS24880	2401204..2401368	+	165	WP_158406100.1	hypothetical protein	-
TOL2_RS11015	2401540..2401791	+	252	WP_014957534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TOL2_RS11020	2401781..2402065	+	285	WP_041279436.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TOL2_RS11025	2402814..2403899	-	1086	WP_014957526.1	transposase	-
TOL2_RS11030	2403896..2404771	-	876	WP_014957527.1	site-specific integrase	-
TOL2_RS11035	2405004..2405198	+	195	WP_014957536.1	type II toxin-antitoxin system HicA family toxin	-
TOL2_RS11040	2405195..2405530	+	336	WP_014957537.1	toxin-antitoxin system HicB family antitoxin	-
TOL2_RS11045	2405637..2406977	-	1341	WP_014957509.1	group II intron reverse transcriptase/maturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-77)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10927.89 Da
• Isoelectric Point: 10.3617

>T28272 WP_041279436.1 NC_018645:2401781-2402065 [Desulfobacula toluolica Tol2]
MSYKLKFLPTALKEWKKLDNSILAQFRKKLKECLEVPHVPSGKLSGFENHYKIKLRASGYRLVYEVIDQELFVLVVAVGK
REKGAVYEKARDRS

Nucleotide

• Length: 285 bp

>T28272 NC_018645:2401781-2402065 [Desulfobacula toluolica Tol2]
ATGAGCTATAAACTAAAGTTTCTCCCAACGGCTCTGAAGGAATGGAAGAAGCTGGATAATTCTATTTTGGCGCAATTCAG
GAAGAAACTGAAAGAGTGTTTGGAGGTACCTCATGTACCCTCCGGTAAGCTTTCCGGCTTTGAGAATCATTACAAAATCA
AACTTAGGGCCAGTGGGTATCGACTTGTGTATGAAGTGATCGATCAAGAATTGTTCGTCCTTGTTGTTGCTGTTGGAAAA
AGAGAAAAAGGTGCTGTGTATGAAAAAGCACGAGACAGATCATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9146.35 Da
• Isoelectric Point: 4.2333

>AT28272 WP_014957534.1 NC_018645:2401540-2401791 [Desulfobacula toluolica Tol2]
MEAVLANCSASISELKKNPSALIDASGGEPIAILNHNKPTAYLIPADTYQQILDRLEDYELGLIVKEREHEKAQAIEVDI
NEL

Nucleotide

• Length: 252 bp

>AT28272 NC_018645:2401540-2401791 [Desulfobacula toluolica Tol2]
ATGGAGGCCGTATTAGCTAACTGTTCAGCAAGTATTTCTGAGTTAAAGAAAAACCCCTCAGCATTGATTGACGCATCAGG
CGGAGAACCCATTGCTATCTTAAACCACAACAAACCAACCGCTTACTTGATCCCAGCCGACACCTATCAGCAAATCCTTG
ATAGGTTGGAGGATTATGAACTCGGACTGATCGTTAAAGAGCGTGAACATGAGAAAGCCCAGGCCATTGAGGTAGATATC
AATGAGCTATAA

Structures

Antitoxin

• AlphaFold DB: K0NPI6