282709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1822381..1823141 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag NED09_RS08710 Protein ID WP_000533912.1
Coordinates 1822656..1823141 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NED09_RS08705 Protein ID WP_000965886.1
Coordinates 1822381..1822668 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS08685 (1817786) 1817786..1818697 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NED09_RS08690 (1818707) 1818707..1820776 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
NED09_RS08695 (1821166) 1821166..1821564 + 399 Protein_1677 IS3 family transposase -
NED09_RS08700 (1821736) 1821736..1822203 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NED09_RS08705 (1822381) 1822381..1822668 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NED09_RS08710 (1822656) 1822656..1823141 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
NED09_RS08715 (1823512) 1823512..1824051 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
NED09_RS08720 (1824225) 1824225..1824437 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NED09_RS08725 (1824725) 1824725..1825015 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NED09_RS08730 (1825454) 1825454..1826164 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NED09_RS08735 (1826214) 1826214..1827188 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
NED09_RS08740 (1827407) 1827407..1828069 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T282709 WP_000533912.1 NZ_CP126166:1822656-1823141 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT282709 WP_000965886.1 NZ_CP126166:1822381-1822668 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References