Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1121722..1122503 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NED09_RS05495 Protein ID WP_000626100.1
Coordinates 1121722..1122213 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NED09_RS05500 Protein ID WP_001110452.1
Coordinates 1122210..1122503 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS05460 (1117182) 1117182..1117529 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
NED09_RS05465 (1117505) 1117505..1119208 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
NED09_RS05470 (1119245) 1119245..1119820 + 576 WP_001188509.1 transcriptional regulator -
NED09_RS05480 (1120091) 1120091..1120165 - 75 Protein_1063 helix-turn-helix domain-containing protein -
NED09_RS05485 (1120545) 1120545..1120622 + 78 Protein_1064 porin family protein -
NED09_RS05490 (1120722) 1120722..1121474 + 753 WP_000842433.1 non-specific acid phosphatase -
NED09_RS05495 (1121722) 1121722..1122213 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NED09_RS05500 (1122210) 1122210..1122503 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NED09_RS05505 (1122820) 1122820..1123041 + 222 WP_001576552.1 hypothetical protein -
NED09_RS05510 (1123307) 1123307..1124182 + 876 WP_000921676.1 AraC family transcriptional regulator -
NED09_RS05515 (1124179) 1124179..1124466 + 288 WP_001541332.1 transcriptional regulator RtsB -
NED09_RS05520 (1124459) 1124459..1124767 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
NED09_RS05525 (1124766) 1124766..1125014 + 249 Protein_1072 Ig-like domain-containing protein -
NED09_RS05530 (1125126) 1125126..1125257 + 132 Protein_1073 hypothetical protein -
NED09_RS05535 (1125551) 1125551..1126456 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T282706 WP_000626100.1 NZ_CP126166:c1122213-1121722 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT282706 WP_001110452.1 NZ_CP126166:c1122503-1122210 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References