Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1014826..1015342 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag NED09_RS04920 Protein ID WP_000220582.1
Coordinates 1014826..1015110 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NED09_RS04925 Protein ID WP_000212724.1
Coordinates 1015100..1015342 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS04905 (1010037) 1010037..1011689 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
NED09_RS04910 (1012098) 1012098..1014236 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NED09_RS04915 (1014358) 1014358..1014822 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NED09_RS04920 (1014826) 1014826..1015110 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NED09_RS04925 (1015100) 1015100..1015342 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NED09_RS04930 (1015420) 1015420..1017333 - 1914 WP_001212142.1 BglG family transcription antiterminator -
NED09_RS04935 (1017350) 1017350..1018090 - 741 WP_000779259.1 KDGP aldolase family protein -
NED09_RS04940 (1018087) 1018087..1019205 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NED09_RS04945 (1019189) 1019189..1020322 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T282705 WP_000220582.1 NZ_CP126166:c1015110-1014826 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT282705 WP_000212724.1 NZ_CP126166:c1015342-1015100 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References