282704

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 973701..974251 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NED09_RS04715 Protein ID WP_001199743.1
Coordinates 973701..974009 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag NED09_RS04720 Protein ID WP_001118105.1
Coordinates 974012..974251 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS04695 (970275) 970275..971015 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
NED09_RS04700 (971137) 971137..971667 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
NED09_RS04705 (971990) 971990..973123 + 1134 Protein_913 IS3 family transposase -
NED09_RS04710 (973155) 973155..973295 - 141 Protein_914 Arm DNA-binding domain-containing protein -
NED09_RS04715 (973701) 973701..974009 - 309 WP_001199743.1 CcdB family protein Toxin
NED09_RS04720 (974012) 974012..974251 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NED09_RS04725 (974360) 974360..974608 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
NED09_RS04730 (974799) 974799..975230 - 432 Protein_918 helix-turn-helix domain-containing protein -
NED09_RS04740 (975987) 975987..977006 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
NED09_RS04745 (977034) 977034..977564 - 531 WP_000896758.1 gluconokinase -
NED09_RS04750 (977781) 977781..978812 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 972082..975185 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T282704 WP_001199743.1 NZ_CP126166:c974009-973701 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT282704 WP_001118105.1 NZ_CP126166:c974251-974012 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References