282703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 929440..930016 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NED09_RS04505 Protein ID WP_001131963.1
Coordinates 929729..930016 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NED09_RS04500 Protein ID WP_000063142.1
Coordinates 929440..929742 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS04485 (925950) 925950..928100 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
NED09_RS04490 (928195) 928195..928398 + 204 WP_000460616.1 YbdD/YjiX family protein -
NED09_RS04495 (928409) 928409..929365 + 957 WP_000187843.1 GTPase -
NED09_RS04500 (929440) 929440..929742 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NED09_RS04505 (929729) 929729..930016 - 288 WP_001131963.1 BrnT family toxin Toxin
NED09_RS04510 (930433) 930433..931689 + 1257 Protein_874 NERD domain-containing protein/DEAD/DEAH box helicase -
NED09_RS04515 (931683) 931683..931862 + 180 Protein_875 DNA methyltransferase -
NED09_RS04520 (931852) 931852..933156 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T282703 WP_001131963.1 NZ_CP126166:c930016-929729 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT282703 WP_000063142.1 NZ_CP126166:c929742-929440 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References