Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 312318..312938 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NED09_RS01525 Protein ID WP_001280991.1
Coordinates 312720..312938 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NED09_RS01520 Protein ID WP_000344807.1
Coordinates 312318..312692 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS01510 (307457) 307457..308650 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NED09_RS01515 (308673) 308673..311822 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NED09_RS01520 (312318) 312318..312692 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NED09_RS01525 (312720) 312720..312938 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NED09_RS01530 (313117) 313117..313668 + 552 WP_001278793.1 maltose O-acetyltransferase -
NED09_RS01535 (313786) 313786..314256 + 471 WP_000136183.1 YlaC family protein -
NED09_RS01540 (314312) 314312..314452 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NED09_RS01545 (314458) 314458..314718 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NED09_RS01550 (314943) 314943..316493 + 1551 WP_000213140.1 EAL domain-containing protein -
NED09_RS01560 (316724) 316724..317113 + 390 WP_000961287.1 MGMT family protein -
NED09_RS01565 (317146) 317146..317715 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T282700 WP_001280991.1 NZ_CP126166:312720-312938 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT282700 WP_000344807.1 NZ_CP126166:312318-312692 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References