Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 37726..39443 Replicon plasmid p4
Accession NZ_CP126149
Organism Sagittula sp. MA-2

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag QNI11_RS25375 Protein ID WP_283983997.1
Coordinates 38805..39443 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag QNI11_RS25370 Protein ID WP_283983996.1
Coordinates 37726..38805 (-) Length 360 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNI11_RS25330 (QNI11_25330) 33325..33597 + 273 WP_283983990.1 WGR domain-containing protein -
QNI11_RS25335 (QNI11_25335) 33713..33907 + 195 Protein_33 hypothetical protein -
QNI11_RS25340 (QNI11_25340) 33921..34289 - 369 WP_283983999.1 DUF6527 family protein -
QNI11_RS25345 (QNI11_25345) 34318..35508 - 1191 WP_283983991.1 ThiF family adenylyltransferase -
QNI11_RS25350 (QNI11_25350) 35483..35743 - 261 WP_283983992.1 multiubiquitin domain-containing protein -
QNI11_RS25355 (QNI11_25355) 35753..35974 - 222 WP_283983993.1 DUF2188 domain-containing protein -
QNI11_RS25360 (QNI11_25360) 36154..36471 + 318 WP_283983994.1 hypothetical protein -
QNI11_RS25365 (QNI11_25365) 36471..37604 + 1134 WP_283983995.1 HigA family addiction module antitoxin -
QNI11_RS25370 (QNI11_25370) 37726..38805 - 1080 WP_283983996.1 macro domain-containing protein Antitoxin
QNI11_RS25375 (QNI11_25375) 38805..39443 - 639 WP_283983997.1 DUF4433 domain-containing protein Toxin
QNI11_RS25380 (QNI11_25380) 39735..40847 - 1113 WP_283983953.1 Fic family protein -
QNI11_RS25385 (QNI11_25385) 40968..41207 - 240 WP_066707423.1 hypothetical protein -
QNI11_RS25390 (QNI11_25390) 41369..42010 - 642 WP_283983954.1 hypothetical protein -
QNI11_RS25395 (QNI11_25395) 42021..42740 - 720 WP_283983955.1 ParA family protein -
QNI11_RS25400 (QNI11_25400) 43293..43511 + 219 WP_283983956.1 hypothetical protein -
QNI11_RS25405 (QNI11_25405) 43529..44191 + 663 WP_283983957.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..77613 77613


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(12-212)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 24286.85 Da        Isoelectric Point: 7.9520

>T282698 WP_283983997.1 NZ_CP126149:c39443-38805 [Sagittula sp. MA-2]
MANLTAEKALIFRITHINNVPWILRHGLHCKNSGVQDPNFVRIGNLELIQRRTARNVPVPPGGTLSDYIPFYFTPFSMMM
YNIKTGYGGIRQFLNAEIVIMASSLRGLADRGVATVFSDRHAYLQTAQFFTSLDDLDKIDWGILQRRDFKRDVDDPEKTD
RYQAEALVHRHLPVEHLAGIVCLSENEKGTLERQREEVGLDLKIVARPGWYF

Download         Length: 639 bp

Antitoxin


Download         Length: 360 a.a.        Molecular weight: 40190.17 Da        Isoelectric Point: 5.8964

>AT282698 WP_283983996.1 NZ_CP126149:c38805-37726 [Sagittula sp. MA-2]
MVTYTRGNLLEADVDAVVNTVNTVGIMGKGIALMFKEQFPRNFEAYARACDAGEVRVGKMFVTENKELFGPRWIINFPTK
THWRVKTKIEWVEDGLKDLVRVIREKEIQSIAIPPLGCGNGGLDWSDVRPLIEASLAELDGVNVIVYEPTSKYQNVAKRT
GVEKLTPARALVAEMVRRYSLLGIECSILEVQKLGWFLERGVTRFGGSDALKFRFQANKYGPYSHNLTKLLDSLDGSYLR
CDKRLADADPMDLIWFNDAKYDRVQAYLNSGEGKQFSSVLEWASATIDGFESPLGMELLATVDWMMQHDDIEPTVEGVME
GLKGWAGGEAAGQRKLKIFDRRLVAIALGQLQTSNRLPA

Download         Length: 1080 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References