Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178813..4179594 Replicon chromosome
Accession NZ_CP126140
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain DSE06

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag QNM21_RS20440 Protein ID WP_000626100.1
Coordinates 4178813..4179304 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag QNM21_RS20445 Protein ID WP_001110452.1
Coordinates 4179301..4179594 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM21_RS20405 (4174273) 4174273..4174620 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
QNM21_RS20410 (4174596) 4174596..4176299 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
QNM21_RS20415 (4176336) 4176336..4176911 + 576 WP_001188509.1 transcriptional regulator -
QNM21_RS20425 (4177182) 4177182..4177256 - 75 Protein_3994 helix-turn-helix domain-containing protein -
QNM21_RS20430 (4177636) 4177636..4177713 + 78 Protein_3995 porin family protein -
QNM21_RS20435 (4177813) 4177813..4178565 + 753 WP_000842433.1 non-specific acid phosphatase -
QNM21_RS20440 (4178813) 4178813..4179304 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
QNM21_RS20445 (4179301) 4179301..4179594 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
QNM21_RS20450 (4179911) 4179911..4180132 + 222 WP_001576552.1 hypothetical protein -
QNM21_RS20455 (4180398) 4180398..4181273 + 876 WP_000921676.1 AraC family transcriptional regulator -
QNM21_RS20460 (4181270) 4181270..4181557 + 288 WP_001541332.1 transcriptional regulator RtsB -
QNM21_RS20465 (4181550) 4181550..4181732 - 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
QNM21_RS20470 (4181857) 4181857..4182105 + 249 Protein_4003 Ig-like domain-containing protein -
QNM21_RS20475 (4182217) 4182217..4182348 + 132 Protein_4004 hypothetical protein -
QNM21_RS20480 (4182642) 4182642..4183547 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T282691 WP_000626100.1 NZ_CP126140:c4179304-4178813 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT282691 WP_001110452.1 NZ_CP126140:c4179594-4179301 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References