Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-AbrB
Location 923901..924477 Replicon chromosome
Accession NC_018645
Organism Desulfobacula toluolica Tol2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag TOL2_RS04280 Protein ID WP_041279249.1
Coordinates 923901..924248 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag TOL2_RS04285 Protein ID WP_041279250.1
Coordinates 924238..924477 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TOL2_RS04220 918977..919228 + 252 WP_041279246.1 hypothetical protein -
TOL2_RS04225 919243..920226 - 984 WP_014956298.1 HipA domain-containing protein -
TOL2_RS04230 920226..920546 - 321 WP_014956299.1 HipA N-terminal domain-containing protein -
TOL2_RS04235 920534..920818 - 285 WP_014956300.1 helix-turn-helix domain-containing protein -
TOL2_RS04240 921099..921383 - 285 WP_014956301.1 type II toxin-antitoxin system RelE/ParE family toxin -
TOL2_RS04245 921380..921649 - 270 WP_014956302.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TOL2_RS04250 921907..922221 - 315 WP_193787654.1 hypothetical protein -
TOL2_RS04255 922322..922639 - 318 WP_014956304.1 nucleotidyltransferase domain-containing protein -
TOL2_RS04260 922615..922926 - 312 WP_051012257.1 HEPN domain-containing protein -
TOL2_RS04265 922926..923264 + 339 WP_014956305.1 Rpn family recombination-promoting nuclease/putative transposase -
TOL2_RS04270 923351..923575 + 225 WP_014956306.1 hypothetical protein -
TOL2_RS04275 923627..923875 + 249 WP_041279248.1 transposase -
TOL2_RS04280 923901..924248 - 348 WP_041279249.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
TOL2_RS04285 924238..924477 - 240 WP_041279250.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
TOL2_RS04290 924870..925133 - 264 WP_014956308.1 Txe/YoeB family addiction module toxin -
TOL2_RS04295 925130..925381 - 252 WP_014956309.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TOL2_RS04300 925509..925718 - 210 WP_014956310.1 type II toxin-antitoxin system HicB family antitoxin -
TOL2_RS04310 926158..926415 + 258 WP_198408354.1 type II toxin-antitoxin system RelE/ParE family toxin -
TOL2_RS04315 926431..926793 + 363 WP_014956311.1 helix-turn-helix domain-containing protein -
TOL2_RS04320 926800..927135 - 336 WP_014956312.1 hypothetical protein -
TOL2_RS04325 927128..927442 - 315 WP_014956313.1 hypothetical protein -
TOL2_RS04330 927519..928541 - 1023 WP_014956314.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-109)

Antitoxin

PrlF antitoxin

(8-50)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12898.14 Da        Isoelectric Point: 9.9197

>T28268 WP_041279249.1 NC_018645:c924248-923901 [Desulfobacula toluolica Tol2]
VAYKIFDVVVVPFPFTDQDTDKRRPALVLSDHARFNDETQNCVMAMVTSAKNPDWPLDVKIGSIKKAGLPAPSKVRMKLF
TLDSRLIVKKIGGLAAKDQEIVKKNLKELMNLETE

Download         Length: 348 bp

>T28268 NC_018645:c924248-923901 [Desulfobacula toluolica Tol2]
GTGGCTTATAAAATTTTTGACGTTGTGGTGGTTCCTTTTCCATTTACTGACCAAGATACGGATAAGAGGCGGCCGGCTTT
AGTGTTGTCAGACCATGCTCGATTTAATGATGAAACTCAAAATTGCGTTATGGCCATGGTAACCAGTGCTAAAAATCCTG
ATTGGCCGCTTGACGTGAAGATAGGCAGTATCAAAAAAGCCGGCCTTCCTGCACCCTCTAAGGTTCGCATGAAGTTATTT
ACACTGGATAGTCGCCTTATTGTAAAAAAGATTGGTGGTCTTGCCGCCAAAGATCAAGAGATTGTAAAAAAAAATCTTAA
AGAATTAATGAATCTTGAGACAGAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8846.12 Da        Isoelectric Point: 8.6012

>AT28268 WP_041279250.1 NC_018645:c924477-924238 [Desulfobacula toluolica Tol2]
MELAINTSKLTTKSQATIPRQIRKLLGLHPGDSVAFEVNENKKVIIRKATPIDFEFAKALEGTLSEWSSKNDEEAYRGL

Download         Length: 240 bp

>AT28268 NC_018645:c924477-924238 [Desulfobacula toluolica Tol2]
ATGGAACTCGCAATCAATACAAGCAAACTGACAACTAAGAGTCAAGCCACTATACCGAGACAGATCAGAAAATTATTGGG
GCTGCACCCCGGCGATTCTGTGGCATTTGAAGTCAATGAAAACAAAAAGGTTATTATACGCAAAGCAACACCAATTGATT
TTGAATTTGCGAAAGCTCTTGAGGGTACACTTTCTGAGTGGTCTTCTAAAAACGATGAAGAGGCATATCGTGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References