Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4248582..4249098 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag QNM33_RS20845 Protein ID WP_000220578.1
Coordinates 4248582..4248866 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QNM33_RS20850 Protein ID WP_000212724.1
Coordinates 4248856..4249098 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS20830 (4243794) 4243794..4245446 + 1653 WP_283995879.1 alpha,alpha-phosphotrehalase -
QNM33_RS20835 (4245855) 4245855..4247993 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QNM33_RS20840 (4248114) 4248114..4248578 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QNM33_RS20845 (4248582) 4248582..4248866 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNM33_RS20850 (4248856) 4248856..4249098 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QNM33_RS20855 (4249176) 4249176..4251089 - 1914 WP_001212137.1 BglG family transcription antiterminator -
QNM33_RS20860 (4251106) 4251106..4251846 - 741 WP_000779263.1 KDGP aldolase family protein -
QNM33_RS20865 (4251843) 4251843..4252961 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QNM33_RS20870 (4252945) 4252945..4254078 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T282668 WP_000220578.1 NZ_CP126138:c4248866-4248582 [Salmonella enterica subsp. enterica serovar Kottbus]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT282668 WP_000212724.1 NZ_CP126138:c4249098-4248856 [Salmonella enterica subsp. enterica serovar Kottbus]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References