Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3505034..3505654 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QNM33_RS17380 Protein ID WP_001280991.1
Coordinates 3505436..3505654 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QNM33_RS17375 Protein ID WP_000344807.1
Coordinates 3505034..3505408 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS17365 (3500173) 3500173..3501366 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QNM33_RS17370 (3501389) 3501389..3504538 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QNM33_RS17375 (3505034) 3505034..3505408 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QNM33_RS17380 (3505436) 3505436..3505654 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QNM33_RS17385 (3505833) 3505833..3506384 + 552 WP_001278792.1 maltose O-acetyltransferase -
QNM33_RS17390 (3506501) 3506501..3506971 + 471 WP_000136181.1 YlaC family protein -
QNM33_RS17395 (3507027) 3507027..3507167 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QNM33_RS17400 (3507173) 3507173..3507433 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QNM33_RS17405 (3507658) 3507658..3509208 + 1551 WP_000213139.1 EAL domain-containing protein -
QNM33_RS17415 (3509439) 3509439..3509828 + 390 WP_000961285.1 MGMT family protein -
QNM33_RS17420 (3509861) 3509861..3510430 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T282663 WP_001280991.1 NZ_CP126138:3505436-3505654 [Salmonella enterica subsp. enterica serovar Kottbus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT282663 WP_000344807.1 NZ_CP126138:3505034-3505408 [Salmonella enterica subsp. enterica serovar Kottbus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References