Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3723849..3724666 Replicon chromosome
Accession NZ_CP126137
Organism Morganella morganii strain Sample-M-2023

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QLX58_RS17610 Protein ID WP_015422406.1
Coordinates 3723849..3724355 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag QLX58_RS17615 Protein ID WP_004236533.1
Coordinates 3724358..3724666 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX58_RS17570 (QLX58_17570) 3719208..3719831 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
QLX58_RS17575 (QLX58_17575) 3719850..3720845 - 996 WP_004236526.1 serine/threonine protein kinase -
QLX58_RS17580 (QLX58_17580) 3720845..3721114 - 270 WP_124537799.1 YihD family protein -
QLX58_RS17585 (QLX58_17585) 3721335..3721907 + 573 Protein_3409 molybdenum cofactor guanylyltransferase MobA -
QLX58_RS17590 (QLX58_17590) 3721914..3722432 + 519 WP_223302449.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
QLX58_RS17595 (QLX58_17595) 3722647..3722949 + 303 WP_004240743.1 HdeA/HdeB family chaperone -
QLX58_RS17600 (QLX58_17600) 3723077..3723598 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
QLX58_RS17605 (QLX58_17605) 3723595..3723735 + 141 WP_004236531.1 hypothetical protein -
QLX58_RS17610 (QLX58_17610) 3723849..3724355 - 507 WP_015422406.1 GNAT family N-acetyltransferase Toxin
QLX58_RS17615 (QLX58_17615) 3724358..3724666 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
QLX58_RS17620 (QLX58_17620) 3724798..3726150 - 1353 WP_124537800.1 glutathione-disulfide reductase -
QLX58_RS17625 (QLX58_17625) 3726219..3727061 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QLX58_RS17630 (QLX58_17630) 3727251..3727640 + 390 WP_004236536.1 DUF1090 domain-containing protein -
QLX58_RS17635 (QLX58_17635) 3728052..3729044 + 993 WP_046024794.1 inner membrane protein YhjD -
QLX58_RS17640 (QLX58_17640) 3729152..3729358 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18565.43 Da        Isoelectric Point: 9.9508

>T282651 WP_015422406.1 NZ_CP126137:c3724355-3723849 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT282651 WP_004236533.1 NZ_CP126137:c3724666-3724358 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References